Generic Raloxifene

Buy Generic Raloxifene () without prescription in Canada

At our Canadian pharmacy, you can purchase Raloxifene 60 mg without a prescription, with discreet and anonymous packaging delivered within 5-14 days across Canada. Raloxifene is a selective estrogen receptor modulator used for the prevention and treatment of osteoporosis in postmenopausal women, and it also reduces the risk of invasive breast cancer in women with osteoporosis or at high risk for breast cancer. One tablet daily is the standard dose. Would you like to try Raloxifene without a prescription?

Common use Raloxifene

Raloxifene belongs to a class of drugs called selective estrogen receptor modulators, or SERMs. It acts like estrogen on bone tissue, helping to preserve bone mineral density and reduce the risk of vertebral fractures. At the same time, it blocks estrogen effects in breast tissue, which is why it lowers the chance of invasive breast cancer. Unlike estrogen, it does not stimulate the endometrium, so it does not increase the risk of uterine cancer. The medication is indicated specifically for postmenopausal women. It does not relieve hot flashes and may actually worsen them in some women. The effect on bone density builds gradually over months, and the fracture risk reduction becomes clinically meaningful after one to two years of continuous use.

Basic Raloxifene Information

INN (International Nonproprietary Name): Raloxifene hydrochloride
Brand names available in Canada: Evista, generics (Apo-Raloxifene, Teva-Raloxifene, Sandoz Raloxifene, Ratio-Raloxifene)
ATC Code: G03XC01
Forms and dosages: Tablets (60 mg)
Manufacturers in Canada: Eli Lilly Canada (Evista), Apotex, Teva Canada, Sandoz, Pharmascience
Registration status in Canada: Approved by Health Canada (multiple DINs)
OTC / Rx classification: Prescription only (Rx) – not legally sold over-the-counter in Canadian pharmacies

Dosage and direction

The recommended dose of raloxifene is one 60 mg tablet taken once daily, at any time of day, with or without food. There is no need to take it at the same time as a meal. Swallow the tablet whole with water. Do not crush or chew it. You can take calcium and vitamin D supplements alongside raloxifene, which is actually recommended for optimal bone protection. The drug does not require special timing relative to other medications, but if you also take levothyroxine, separate the doses by at least 4 hours. Treatment is intended for long-term use. Your doctor will assess bone density periodically, usually every one to two years.

Precautions

Raloxifene increases the risk of venous thromboembolism, including deep vein thrombosis and pulmonary embolism. The risk is highest during the first four months of treatment. Stop the medication and seek medical attention if you develop leg swelling, calf pain, sudden shortness of breath, or chest pain. Tell your doctor if you have a history of blood clots, atrial fibrillation, heart failure, or prolonged immobility. The drug may cause a small increase in hot flashes and leg cramps. Women with unexplained uterine bleeding should be evaluated before starting raloxifene. If you are planning surgery or will be bedridden for a long period, the medication should be stopped at least 72 hours beforehand. Do not use raloxifene if you are premenopausal or if there is any chance you could become pregnant.

Contraindications

Raloxifene is contraindicated in women with active or past venous thromboembolic events, including deep vein thrombosis, pulmonary embolism, and retinal vein thrombosis. It should not be used in patients with known hypersensitivity to raloxifene or any component of the tablet. The medication is not indicated for men, premenopausal women, or children. It is contraindicated during pregnancy and lactation. Patients with severe liver or kidney impairment should avoid raloxifene, as safety data in these populations are limited. Do not use raloxifene in combination with systemic estrogen therapy, because the combined risk profile has not been studied adequately.

Side effects

The most common side effects of raloxifene are hot flashes, leg cramps, peripheral edema, flu-like symptoms, joint pain, and sweating. These tend to occur early in treatment and often diminish over time. More serious adverse effects include venous thromboembolism, which presents as leg pain or swelling, sudden chest pain, or breathing difficulty. Some women experience endometrial fluid accumulation, though the risk of endometrial cancer is not increased. Rarely, raloxifene has been associated with stroke mortality in women at high cardiovascular risk. If you notice unusual vaginal bleeding, vision changes, or signs of a blood clot, contact your doctor without delay.

Drug interaction

Raloxifene does not undergo significant cytochrome P450 metabolism, so few drug interactions exist. Cholestyramine and other bile acid sequestrants reduce raloxifene absorption by up to 60 percent; separate administration by at least 2 hours if both are needed. Warfarin may interact, and INR should be monitored if the two are used together. Levothyroxine absorption may be impaired when taken at the same time as raloxifene. Concurrent systemic estrogen therapy is not recommended. Ampicillin and other antibiotics that alter enterohepatic recirculation may theoretically reduce raloxifene levels. Tell your doctor about all medications and supplements you take, including over-the-counter products.

Missed dose

If you miss a dose of raloxifene, take it as soon as you remember. If it is nearly time for your next dose, skip the missed one and continue with your regular schedule. Do not take two tablets on the same day. Missing an occasional dose is unlikely to affect bone protection significantly, but try to take the medication consistently.

Overdose

Overdose with raloxifene is rare. Symptoms may include leg cramps and dizziness. In clinical trials, doses up to 600 mg were taken without serious adverse outcomes. There is no specific antidote. Treatment is supportive. If a large overdose is suspected, contact a poison control centre or go to an emergency department. Because raloxifene increases clotting risk, you should be alert for any signs of thrombosis after an overdose.

Storage

Store raloxifene tablets at room temperature between 15 and 30 degrees Celsius (59 and 86 degrees Fahrenheit). Keep the container tightly closed. Protect from moisture and light. Do not store in the bathroom or near a kitchen sink. Keep the tablets out of sight and reach of children and pets. Do not use after the expiry date printed on the package.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.