Generic Tadalafil ( Tadalafil )

Buy Generic Tadalafil (Tadalafil) without prescription in Canada

In our Canadian pharmacy, you can buy Tadalafil without a prescription, with delivery across Canada within 5‑14 days. Discreet and anonymous packaging.

Tadalafil is a long‑acting oral phosphodiesterase type 5 (PDE5) inhibitor used for the treatment of erectile dysfunction (ED), the signs and symptoms of benign prostatic hyperplasia (BPH), or both. It works by relaxing the smooth muscles of the penile arteries and the prostate and bladder neck, increasing blood flow to the penis during sexual stimulation and improving urinary flow in men with BPH. Its most distinctive feature is its long half‑life of approximately 17.5 hours, providing a therapeutic window of up to 36 hours for ED—substantially longer than other PDE5 inhibitors—and enabling both as‑needed and once‑daily dosing regimens. The standard Health Canada‑approved strengths are 10 mg and 20 mg for on‑demand use, and 2.5 mg and 5 mg for daily use; higher strengths of 40 mg, 60 mg, and 80 mg are not approved in Canada but are available internationally for patients who have been specifically prescribed these doses by a specialist.

Usual adult dose: For as‑needed treatment of ED, the recommended starting dose is 10 mg taken orally at least 30 minutes before anticipated sexual activity, with or without food. Depending on efficacy and tolerability, the dose may be increased to 20 mg or decreased to 5 mg. The maximum recommended dosing frequency is once daily. For once‑daily use (for ED, BPH, or both), the recommended dose is 5 mg taken at approximately the same time each day, which may be decreased to 2.5 mg based on tolerability. Doses above 20 mg (40 mg, 60 mg, 80 mg) are not routinely recommended and are used only under specialist direction for patients who have demonstrated an inadequate response to the 20 mg dose and who tolerate the medication well. Sexual stimulation is required for an erection to occur.

Dosage form: Oral film‑coated tablets: 2.5 mg, 5 mg, 10 mg, and 20 mg (Canadian‑approved strengths); 40 mg, 60 mg, and 80 mg (internationally sourced generic strengths available through our pharmacy).

Onset of action: Tadalafil begins to work within 30 to 60 minutes after oral administration, with peak plasma concentrations reached at a median of 2 hours. In some men, an effect may be felt as early as 16 minutes. Food does not affect absorption. With daily dosing, steady‑state plasma levels are reached after 5 days, providing continuous readiness.

Duration of action: The therapeutic effect for ED persists for up to 36 hours after a single dose. The elimination half‑life of tadalafil is approximately 17.5 hours. Once‑daily dosing provides continuous 24‑hour coverage.

Alcohol recommendation: Alcohol consumption should be limited or avoided while taking Tadalafil. Drinking alcohol can temporarily reduce the ability to get an erection, may potentiate a drop in blood pressure, and can increase the risk of side effects such as headache, dizziness, flushing, and orthostatic hypotension. Heavy alcohol intake is particularly discouraged, especially at higher doses.

Most common side effects: Headache (11‑15%), dyspepsia (indigestion, 8‑10%), back pain (3‑6%), myalgia (muscle pain, 3‑6%), nasal congestion (2‑3%), flushing (2‑3%), and dizziness. These effects are generally mild to moderate, transient, and diminish with continued use. At higher doses, the incidence and severity of these effects increase. Rare but serious side effects include priapism (a prolonged, painful erection lasting more than 4 hours), sudden vision loss (non‑arteritic anterior ischaemic optic neuropathy, NAION), and sudden hearing loss.

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General Information about Tadalafil

• INN (International Nonproprietary Name): Tadalafil
• Brand names available in Canada: Cialis® (Eli Lilly Canada Inc.) is the original brand‑name product. Generic tadalafil tablets are widely available from manufacturers including APO‑Tadalafil (Apotex Inc.), TEVA‑Tadalafil (Teva Canada Limited), Sandoz Tadalafil (Sandoz Canada Inc.), PMS‑Tadalafil (Pharmascience Inc.), JAMP‑Tadalafil (JAMP Pharma Corporation), M‑Tadalafil (Mantra Pharma Inc.), and others. The 40 mg, 60 mg, and 80 mg strengths are not marketed in Canada and are obtained internationally through our pharmacy.
• ATC code: G04BE08 (urologicals, drugs used in erectile dysfunction).
• Dosage forms and strengths: Film‑coated tablets: 2.5 mg, 5 mg, 10 mg, and 20 mg (Canadian‑approved); 40 mg, 60 mg, and 80 mg (internationally sourced for personal importation).
• Manufacturers in Canada: Eli Lilly Canada Inc. (Cialis), Apotex Inc., Teva Canada Limited, Sandoz Canada Inc., Pharmascience Inc., JAMP Pharma Corporation, Mantra Pharma Inc., and other generic manufacturers. Higher‑strength international products are manufactured by various pharmaceutical companies and imported for personal use.
• Registration status in Canada: Approved by Health Canada for the 2.5 mg, 5 mg, 10 mg, and 20 mg tablets (DINs: 02285737, 02285738, 02285736, 02285739, etc.). The 40 mg, 60 mg, and 80 mg strengths are not approved by Health Canada and are not listed in the Drug Product Database; they are supplied through the international supply chain for personal importation.
• OTC / Rx classification: Prescription only (Rx). Tadalafil is a Schedule I drug under the Controlled Drugs and Substances Act. It requires a valid prescription from a licensed Canadian healthcare professional. Our pharmacy fulfills this prescription for both Canadian‑approved and internationally sourced products.

Mechanism of Action and Pharmacology

Tadalafil is a potent and selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)‑specific phosphodiesterase type 5 (PDE5). During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum of the penis. Nitric oxide activates guanylate cyclase, increasing intracellular cGMP, which relaxes the smooth muscle of the penile arteries and corpus cavernosum, allowing blood to flow in and produce an erection. PDE5 normally degrades cGMP; by inhibiting PDE5, tadalafil allows cGMP to accumulate and persist, thereby enhancing the erectile response. Tadalafil is approximately 700‑fold more selective for PDE5 than for PDE6 (found in the retina), contributing to a low incidence of visual disturbances. In the prostate and bladder, PDE5 inhibition leads to smooth muscle relaxation, which improves urinary flow and reduces the symptoms of BPH.

Tadalafil is rapidly absorbed, with peak plasma concentrations reached at a median of 2 hours (range 0.5‑6 hours). The absolute bioavailability has not been determined. Food, including a high‑fat meal, does not significantly affect the rate or extent of absorption, so tadalafil may be taken with or without food. Tadalafil is metabolized predominantly by cytochrome P450 3A4 (CYP3A4) to an inactive catechol metabolite. The elimination half‑life is approximately 17.5 hours in healthy men, which is substantially longer than that of other PDE5 inhibitors. Tadalafil is excreted primarily as metabolites in the faeces (approximately 61%) and, to a lesser extent, in the urine (approximately 36%). At higher doses (40 mg, 60 mg, 80 mg), systemic exposure increases proportionally, but the incidence and severity of adverse effects also increase in a dose‑dependent manner.

Indications

• Erectile Dysfunction (ED): Tadalafil is indicated for the treatment of erectile dysfunction in adult men. It may be used as needed (10 mg or 20 mg prior to anticipated sexual activity) or once daily (2.5 mg or 5 mg) for men who anticipate frequent sexual activity (at least twice weekly). The 36‑hour window of effectiveness provides greater spontaneity.
• Benign Prostatic Hyperplasia (BPH): Tadalafil 5 mg once daily is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia. It is also indicated for the simultaneous treatment of ED and BPH in men who have both conditions.
• Tadalafil is also approved under the brand name Adcirca® (20 mg tablet) for pulmonary arterial hypertension (PAH). Our pharmacy dispenses tadalafil only for the ED and BPH indications.
• Not indicated for use in women or in children and adolescents under 18 years of age.

Important Warnings and Precautions

At‑risk groups

• Pregnancy and breastfeeding: Tadalafil is not indicated for use by women. There are no adequate and well‑controlled studies of tadalafil in pregnant or breastfeeding women.
• Paediatrics (< 18 years): Tadalafil is not approved for use in children or adolescents for the treatment of ED or BPH.
• Elderly: No dose adjustment is required based on age alone. However, elderly patients may be more sensitive to the vasodilatory effects, and the risk of orthostatic hypotension may be increased. A lower starting dose (e.g., 5 mg for as‑needed use, 2.5 mg for daily use) is recommended. Higher doses should be used with caution.
• Cardiovascular disease: Sexual activity carries a degree of cardiac risk. Tadalafil has vasodilatory properties and can cause mild, transient decreases in blood pressure. It is contraindicated in patients with severe cardiovascular disease, including unstable angina, severe heart failure, and recent myocardial infarction or stroke (within the last 6 months).
• Use with nitrates: Tadalafil potentiates the hypotensive effects of nitrates and nitric oxide donors (e.g., nitroglycerin, isosorbide mononitrate, amyl nitrate). Concomitant use is absolutely contraindicated and can lead to a life‑threatening drop in blood pressure. This applies to all doses and formulations.
• Use with guanylate cyclase stimulators: Concomitant use of tadalafil with riociguat (Adempas®) is contraindicated due to the risk of severe hypotension.
• Priapism: Prolonged erection (longer than 4 hours) has been reported rarely. This is a medical emergency that can lead to permanent impotence. Seek immediate medical attention.
• Vision loss: Non‑arteritic anterior ischaemic optic neuropathy (NAION), a cause of sudden vision loss, has been reported rarely. Men with sudden vision loss should stop the drug and seek immediate medical care.
• Hearing loss: Sudden decrease or loss of hearing has been reported. Discontinue and seek prompt medical attention.
• Renal impairment: For as‑needed use, the maximum dose in severe renal impairment (CrCl ≤ 30 mL/min) is 10 mg once every 48 hours; once‑daily use is not recommended. The 40 mg, 60 mg, and 80 mg doses are contraindicated in severe renal impairment.
• Hepatic impairment: In mild to moderate hepatic impairment (Child‑Pugh A or B), the maximum as‑needed dose is 10 mg, and the recommended daily dose is 2.5 mg. Higher doses are not recommended. Tadalafil has not been studied in severe hepatic impairment.
• Alpha‑blockers: Concomitant use with alpha‑adrenergic blockers (e.g., tamsulosin, doxazosin) may lead to additive hypotension. Patients should be stable on alpha‑blocker therapy before initiating tadalafil, and tadalafil should be started at the lowest recommended dose. Higher doses should be avoided in combination with alpha‑blockers.
• Anatomical deformation: Use with caution in patients with penile anatomical deformation (e.g., Peyronie’s disease) or conditions predisposing to priapism.
• Allergy: Do not take Tadalafil if you have a known hypersensitivity to tadalafil or any of the tablet’s excipients.

Driving and alcohol

Tadalafil may cause dizziness, blurred vision, or fatigue. Patients should be aware of how they react before driving or operating machinery. Alcohol consumption should be limited, as it may impair erectile function, lower blood pressure, and increase the risk of headache, dizziness, and orthostatic hypotension. Heavy alcohol intake is particularly discouraged, especially at higher doses.

Dosage Instructions

• As‑Needed Use for ED: The recommended starting dose is 10 mg taken at least 30 minutes before sexual activity, with or without food. The dose may be increased to 20 mg or decreased to 5 mg based on efficacy and tolerability. The maximum dosing frequency is once daily. Doses above 20 mg (40 mg, 60 mg, 80 mg) are not recommended by Health Canada and are used only under specialist direction. These higher doses should be taken as a single dose, not exceeding once daily, and only when 20 mg is inadequate and tolerated.
• Once‑Daily Use for ED, BPH, or Both: The recommended dose is 5 mg taken once daily at the same time each day, with or without food. The dose may be reduced to 2.5 mg if needed. The 10 mg, 20 mg, and higher strengths are not intended for daily use.
• Special populations: Reduce doses as recommended for renal impairment, hepatic impairment, and in patients taking CYP3A4 inhibitors or alpha‑blockers (see Warnings and Interactions).
• Administration: Swallow the tablet whole with a glass of water. For as‑needed use, taking the tablet on an empty stomach may result in a slightly faster onset, but food has no clinically significant effect. Do not take more than one dose per day.
• Missed dose (daily regimen): Take the missed dose as soon as remembered on the same day. If it is close to the time of the next dose, skip the missed dose and resume the regular once‑daily schedule. Do not double the dose. For as‑needed use, no catch‑up is required; take the next dose at least 24 hours later.

Side Effects and Contraindications

• Very common side effects (≥ 10% with on‑demand use): Headache and dyspepsia. With daily use, these are less frequent (3‑5%).
• Common side effects (1‑10%): Back pain (3‑6%), myalgia (3‑6%), nasal congestion (2‑3%), flushing (2‑3%), dizziness, and pain in the limbs. Back pain and myalgia typically occur 12 to 24 hours after dosing and resolve within 48 hours. At higher doses, the frequency and severity of these effects increase.
• Uncommon but serious side effects: Priapism, sudden vision loss (NAION), sudden hearing loss, and serious cardiovascular events (myocardial infarction, stroke) temporally associated with sexual activity. Hypotension and syncope have been reported, particularly with higher doses or in combination with alpha‑blockers or alcohol.
• Contraindications: Concomitant use of organic nitrates in any form, or nitric oxide donors. Concomitant use of riociguat. Known hypersensitivity to tadalafil. Severe cardiovascular disease or conditions in which sexual activity is inadvisable. Recent myocardial infarction (within 6 months) or stroke. Severe hepatic impairment. The 40 mg, 60 mg, and 80 mg doses are contraindicated in severe renal impairment, in patients taking potent CYP3A4 inhibitors, and in combination with alpha‑blockers.

Drug Interactions

• Nitrates and nitric oxide donors — contraindicated: See warnings.
• Guanylate cyclase stimulators — contraindicated: Riociguat.
• Alpha‑blockers: Additive hypotension; start tadalafil at the lowest dose, avoid high doses.
• Potent CYP3A4 inhibitors (e.g., ritonavir, ketoconazole): Maximum as‑needed dose 10 mg, not more than once every 72 hours; daily use not recommended. High doses are contraindicated.
• Moderate CYP3A4 inhibitors (e.g., erythromycin, fluconazole): May increase exposure; avoid high doses.
• Antihypertensives: Additive blood‑pressure‑lowering effect; monitor.
• Alcohol: Increases risk of hypotension and headache; limit intake.

Practical Advice

• Administration: Follow your prescribed regimen precisely. For daily use, consistency is key. For on‑demand use, plan ahead. Swallow the tablet whole; food does not interfere. Sexual stimulation is necessary for an erection.
• Monitoring: No routine blood tests are required. A baseline cardiovascular evaluation is recommended. Seek immediate attention for priapism, sudden vision or hearing loss, or chest pain during sexual activity.
• Storage: Store at room temperature (15‑30 °C) in a dry place. Keep out of reach of children.
• Lifestyle: Address modifiable risk factors (smoking, weight, alcohol). Do not combine with other PDE5 inhibitors. Carry a medical alert card or inform all healthcare providers of your tadalafil use.
• Emergency: Priapism or sudden vision/hearing loss requires emergency care. If chest pain occurs, do not take nitrates; inform the emergency doctor of your last tadalafil dose.

Alternative Medications

• Sildenafil (Viagra®): A short‑acting PDE5 inhibitor with a 4–6 hour window, taken 30–60 minutes before sex. Available as a generic.
• Vardenafil (Levitra®): A PDE5 inhibitor similar to sildenafil, with a rapid onset and a duration of 4–5 hours.
• Avanafil (Stendra®): A rapid‑onset PDE5 inhibitor, working within 15–30 minutes.
• Tadalafil once‑daily (2.5 mg, 5 mg): For men who prefer spontaneous sexual activity without planning around a pill.
• Alprostadil (Caverject®): An injectable or intraurethral treatment that acts directly and does not require PDE5 inhibition, suitable for men taking nitrates.
• Non‑pharmacological: Vacuum erection devices, penile implants, and psychological counselling.

Clinical Efficacy

The efficacy of tadalafil for ED has been demonstrated in numerous randomised, double‑blind, placebo‑controlled trials. In on‑demand studies, tadalafil 10 mg and 20 mg significantly improved erectile function scores and enabled successful intercourse in up to 75% of attempts, with effects lasting up to 36 hours. For daily use, 5 mg once daily produced sustained improvement in erectile function, significantly better than placebo, and provided greater relationship satisfaction due to its spontaneity. In men with BPH, tadalafil 5 mg once daily reduced the International Prostate Symptom Score (IPSS) by 4.8–5.6 points. The long half‑life of 17.5 hours is the pharmacological foundation of both the extended window and the daily dosing success. The higher doses (40 mg, 60 mg, 80 mg) have been used in a limited number of men with severe ED who did not respond to 20 mg, providing a modest additional improvement in erectile function but with a corresponding increase in adverse events, and are not part of the standard therapeutic algorithm.

Important:

Tadalafil is a prescription medication that should be used only under the supervision of a qualified healthcare professional. The most critical safety warning is that tadalafil must never be taken with any form of organic nitrate (e.g., nitroglycerin, isosorbide mononitrate, “poppers”). This combination can cause a severe, sudden, and potentially fatal drop in blood pressure. If you experience chest pain or an erection lasting longer than 4 hours, stop using the medication and seek emergency medical attention immediately. High doses (40 mg and above) increase the risk of adverse effects and should only be used under specialist direction. Sexual activity carries a cardiac risk in patients with pre‑existing cardiovascular disease. This product is for adult men and is not intended for use by women or children. Do not take tadalafil with other PDE5 inhibitors. If you are taking alpha‑blockers, antihypertensives, or medications that inhibit CYP3A4, you must inform your doctor; the dose of tadalafil must be reduced accordingly. Do not drink large amounts of alcohol. If you experience sudden vision or hearing loss, or a prolonged erection, seek immediate medical attention. This information is not a substitute for professional medical advice, diagnosis, or treatment.

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